Patients with chronic kidney disease found to have treatment-resistant hypertension
The American Society of Nephrology Clinical Journal has published new findings that patients with Chronic Kidney Disease (CKD) are at risk for treatment-resistant high blood pressure.

The American Heart Association defines resistant hypertension as blood pressure that remains above goal despite the simultaneous use of four antihypertensive medications of different classes.

The study of 10,700 multi-racial participants of 45 years and older who were being treated for high blood pressure, showed that the rate of apparent treatment-resistant hypertension was 28.1 percent among those with CKD and 13.6 percent among those with normal kidney function.

Researchers, including Paul Muntner, PhD, of the University of Alabama at Birmingham, also found that more than half (56.4%) of patients who had the worst kidney function also had treatment-resistant hypertension.

Within the group studied with CKD, there was a lower risk of treatment-resistant hypertension in women and greater risks in relation to black race, larger waist circumference, diabetes, a history of heart attack or stroke, statin use, and worsening renal function. Other factors considered included geographic region, income, education, physical activity, smoking status, and alcohol use.

The findings of this study “indicate that apparent treatment-resistant hypertension is a common condition among individuals with chronic kidney disease, suggesting the need for greater awareness of this comorbidity among clinicians,” Muntner and colleagues wrote. Furthermore, “the results emphasize the need for the development and dissemination of appropriate therapeutic regimens for chronic kidney disease patients with apparent treatment-resistant hypertension.”

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