Study finds that high blood pressure medication is more effective if taken at bedtime.

A new study has found that patients with type 2 diabetes who take their medicine for nocturnal hypertension before bed, may have better blood pressure control than those who take it in the morning.

Previous research holds that nocturnal blood pressure may be “a stronger independent risk factor for cardiovascular disease than daytime blood pressure.” This led researchers of the current study to explore whether bedtime dosing of once-daily antihypertensive medication reduced nighttime blood pressure without a subsequent increase in daytime blood pressure.

The study involved 41 type 2 diabetes patients with a nocturnal systolic blood pressure reading over 120 mm Hg. These patients were told to take all of their once-daily antihypertensive drugs either in the morning or at night for the first 8 weeks, and then to do the opposite for the next 8 weeks. Blood pressure and blood and urine were tested at baseline and after each 8-week period. Participants took an average of 3 once-daily antihypertensive drugs.

According to the results, presented at the European Association for the Study of Diabetes annual meeting, bedtime dosing showed a significant 7.5 mm Hg decrease in nighttime systolic blood pressure. When patients took their medications at night, 24-hour systolic blood pressure was also significantly improved when compared with morning dosing.

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